The greylist database grows over time, because the greylist server
never removes database entries. If left unattended, the greylist
database will eventually run your file system out of space.
When the status file size exceeds some threshold you can simply
rename or remove the file without adverse effects; Postfix
automatically creates a new file. In the worst case, new mail will
be delayed by an hour or so. To lessen the impact, rename or remove
the file in the middle of the night at the beginning of a weekend.