With Samba-2.2.x, the choice you have is to enable or disable roaming profiles support. It is a global-only setting. The default is to have roaming profiles, and the default path will locate them in the user's home directory.

If disabled globally, then no one will have roaming profile ability. If enabled and you want it to apply only to certain machines, then on those machines on which roaming profile support is not wanted, it is necessary to disable roaming profile handling in the registry of each such machine.

With Samba-3, you can have a global profile setting in smb.conf, and you can override this by per-user settings using the Domain User Manager (as with MS Windows NT4/200x).

In any case, you can configure only one profile per user. That profile can be either: